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Seventy-five percent of all cases of severe liver damage reported until early 2001 were seen under combined drug therapy Arava plus methotrexate.
Therefore, combined drug therapy with anakinra and any TNF-blocking agent is not recommended and should be avoided.
TREATMENT: Antibiotics or combined drug therapy.
These advances were furthered by implementing new TB treatment protocols that substituted physical activity for bed rest and; prescribed a combined drug therapy using streptomycin, INH, and para-Aminosalicylic acid.