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In 1899 Doyne discovered colloid bodies lying on Bruch's membrane that appeared to merge, forming a mosaic pattern that resembled a honeycomb.
Atrophy of the colloid bodies is lined by Hürthle cells, cells with intensely eosinophilic, granular cytoplasm, a metaplasia from the normal cuboidal cells that constitute the lining of the thyroid follicles.