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The cold receptors play an important part in the animal's sense of smell, telling wind direction.
The cold receptors in the skin respond to the place where evaporation is the highest.
Warm and cold receptors play a part in sensing innocuous environmental temperature.
For cold receptors their firing rate increases during cooling and decreases during warming.
Max von Frey found and described these heat and cold receptors and, in 1896, reported finding "pain spots" on the skin of human subjects.
The human body contains 24,000 cold receptors and only 3,000 warm receptors, and therefore freezing is much more dangerous than overheating.
Cold receptors in the skin are sensitive to the cooling of the skin by evaporation of the moisture by air currents.
The transduction of temperature in cold receptors is mediated in part by the TRPM8 channel.
A certain proportion of Aδ fibers are also associated with sensations of temperature (also known as 'cold receptors' in mammals) and pressure.
It has been suggested that it is the constellation of various thermally sensitive proteins together in a neuron that gives rise to a cold receptor.
I have found that adding stimulation for the heat and cold receptors is most effective in getting what I want out of those I interro- gate."
Some cold receptors also respond with a brief action potential discharge to high temperatures, i.e. typically above 45 C, and this is known as a paradoxical response to heat.
The speculation is that lingual cold receptors deliver information that modulates the sense of taste; i.e. some foods taste good when cold, while others do not.
In a search for compounds that activated the TRPM8 cold receptor, compounds that produce a cooling-sensation were sought out from the fragrance industries.
Menthol is a mild anesthetic that excites cold receptors in the mouth, throat and airways, causing a slight numbing sensation that can make tobacco smoke seem less harsh.
The sensitive cold receptors in the skin detect the place where the nose is cooled the most and this is the direction a particular smell that the animal just picked up comes from.
In the cornea cold receptors are thought to respond with an increase in firing rate to cooling produced by evaporation of lacrimal fluid 'tears' and thereby to elicit a reflex blink.
The feeling of freshness associated with the activation of cold receptors by menthol, particularly those in facial areas with axons in the trigeminal (V) nerve, accounts for its use in numerous toiletries including toothpaste, shaving lotions, facial creams and the like.
Distinguishing between the hypotheses that the bitter taste of orange juice results from stannous fluoride or from sodium lauryl sulfate is still an unresolved issue and it is thought that the menthol added for flavor may also take part in the alteration of taste perception when binding to lingual cold receptors.