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Until recently, the vesicular transport mechanism was favoured but now more evidence is coming to light to support cisternal maturation.
Proteins that have been successfully delivered to the Golgi apparatus advance through cisternal progression.
The ER membrane pumps calcium ions from the cytosol into the cisternal space.
One is known as cisternal maturation where the VTC simply matures into the cis-Golgi network.
"Intracranial tumors: cisternal angle as a measure of midbrain compression for assessing risk of postembolization clinical deterioration."
Cisternal maturation model: the cisternae of the Golgi apparatus move by being built at the cis face and destroyed at the trans face.
Translocators can also move polypeptides (such as damaged proteins targeted for proteasomes) from the cisternal space of the endoplasmic reticulum to the cytosol.
When CSF cannot be obtained from the lumbar space (and when its analysis is considered critical to treatment), a cisternal tap may be required.
The phospholipid membrane encloses a space, the cisternal space (or lumen), which is continuous with the perinuclear space but separate from the cytosol.
This highly convoluted space is called the ER lumen and is also referred to as the ER cisternal space.
Consequently, many of the proteins found in the cisternal space of the endoplasmic reticulum lumen are there only temporarily as they pass on their way to other locations.
In general, globular proteins and albumin are in lower concentration in ventricular CSF compared to lumbar or cisternal fluid.
Gametocyte elongation is driven by the assembly of a system of flattened cisternal membrane compartments underneath the parasite plasma membrane and has a supporting network of microtubules.
Immunoelectron microscopy suggests that VSIV G protein moves from cis to trans Golgi bodies without being transported between them in vesicles, supporting the cisternal maturation model of Golgi trafficking.
In eukaryotes the term translocon most commonly refers to the complex that transports nascent polypeptides with a targeting signal sequence into the interior (cisternal or lumenal) space of the endoplasmic reticulum (ER) from the cytosol.
The significance of positive CSF cytology in samples obtained within the first 7 to 10 days of diagnosis is unclear, as is the significance of tumor cells in cisternal fluid obtained at the time of surgery.
A suboccipital puncture or cisternal puncture is a diagnostic procedure that can be performed in order to collect a sample of cerebrospinal fluid (CSF) for biochemical, microbiological, and cytological analysis, or rarely to relieve increased intracranial pressure.
The signal sequence in preprogastrin - that is, residues 1-21, is sufficient to ensure sequestration into the cisternal space of the endoplasmic reticulum so that the peptides we have measured are likely to be localised to the secretory pathway, most probably taking the constitutive route to the exterior.
The cisternal tap may be used in myelography when the upper margin of a spinal block needs to be defined, however, magnetic resonance imaging (MRI), has become the procedure of choice for defining the upper and lower limits of spinal cord or spinal cord compressing lesions.