chromosome breakage
chromosome break

In new mutations, the mechanism causing chromosome breakage is unknown.

She was also able to show that, in some plants, spontaneous chromosome breakage occurred in the cells of the endosperm.

McClintock, while at the Carnegie Institution, continued previous studies on the mechanisms of chromosome breakage and fusion in maize.

Psoralen combined with ultraviolet radiation causes DNA cross-linking and hence chromosome breakage.

McClintock studied transposon-mediated mutation and chromosome breakage in maize and published her first report in 1948 on transposable elements or transposons.

She identified a particular chromosome breakage event that always occurred at the same locus on maize chromosome 9, which she named the "Ds" or "dissociation" locus.

In micronucleus Test, cells are examined for micronuclei, which are fragments or chromosomes left behind at anaphase, and is therefore a test for clastogenic agents that cause chromosome breakages.

A recent screen for spontaneous duplications in yeast suggests that replication-dependent chromosome breakages also play a significant role in generating tandem duplications, because duplication breakpoints are enriched at replication termination sites (Koszul et al. 2004).

The formation of a neocentromere must be coupled with or followed or proceeded by the inactivation of the centromere since chromosomes with two functional centromeres (Dicentric chromosome) will result in chromosome breakage during mitosis.

A simple interpretation of these data is that RecA, RecFOR, and RecQJ functions (and RecET functions for the sbcA background) repair chromosome breakage and/or prevent generation of the breakage.

Persons with Bloom syndrome have an enormous increase in exchange events between homologous chromosomes or sister chromatids (the two DNA molecules that are produced by the DNA replication process); and there are increases in chromosome breakage and rearrangements compared to persons who do not have Bloom's syndrome.

The grey regions indicate either chromosome breaks or missing data.

Chemotherapy may cause chromosome breaks interfering with normal results.

In time, these nicks also cause full chromosome breaks, which could lead to severe mutations and cancers.

Without it, the algae would suffer chromosome breaks and DNA mutations.

Cells of affected individuals have reduced lifespan in culture, more chromosome breaks and translocations and extensive deletions.

But the team suggested that it might still cause chromosome breaks, by acting as a target for other enzymes that can cut DNA.

His research interests have included molecular genetics of Drosophila melanogaster, organization of genes; and mechanism of repair of chromosome breaks.

Since the RAD51C protein is involved in repairing double strand chromosome breaks, this chromosomal rearrangement could be responsible for the other rearrangements.

This higher consistency stems from that fact that, while nucleotide characters have only four possible states to change to and from, chromosome breaks can occur at many different locations.

Therefore, it is much simpler to change from an A to a T in two unrelated lineages than it is to have the exact same chromosome break in those same lineages.

The types of aberrations detected in cells affected by a genotoxic substance are chromatid and chromosome gaps, chromosome breaks, chromatid deletions, fragmentation, translocation, complex rearrangements, and many more.

Cells deficient in Artemis are more sensitive than normal cells to X-rays and to chemical agents that induce double-strand breaks (DSBs), and they show a higher incidence of chromosome breaks following irradiation.

They also refer to a 1997 study published in the Proceedings of the National Academy of Sciences (a journal that publishes papers written by academy members) that linked deficiencies in folic acid to subsequent chromosome breaks.

These diseases are associated with high incidence of chromosomal abnormalities, including chromosome breaks, complex rearrangements, deletions and translocations, site specific mutations, and in particular sister chromatid exchanges (more common in BS) that are believed to be caused by a high level of somatic recombination.