chondrocyte

This gene is also known as hypertrophic chondrocyte specific 24 (hcs24).

The effects of both particle types on chondrocyte growth were minimal at the concentration employed.

Much of her research career was devoted to the study of cartilage and chondrocyte biology.

A review evaluating autologous chondrocyte implantation was published in 2010.

It is thought that normal chondrocyte proliferation and differentiation may be affected, leading to abnormal bone growth.

Yet, the cell culture conditions either quickly reverse cellular phenotype or support normal chondrocyte maturation.

Frank arthritis has been reported in children due to frostbite from extreme cold causing direct chondrocyte injury.

Comparative studies have established that bat digits undergo a more rapid rate of chondrocyte proliferation.

( ii ) There is increased recruitment of precursor cells into the chondrocyte cell lineage.

Their studies showed that chondrocyte death was most highly correlated with the degree of joint inflammation present 14 days after arthritis induction.

Autologous chondrocyte implantation, a medical treatment for articular cargilage damage.

These results point to a role of Hoxc-8 in regulation of cartilage maturation and chondrocyte differentiation.

It is involved in chondrocyte differentiation, proliferation and maturation especially during endochondral ossification.

Autologous chondrocyte implantation for full thickness cartilage defects of the knee.

Here, we have adapted the system to neonatal mouse rib chondrocytes, to study the role of Hoxc-8 in chondrocyte maturation.

That finding suggests that sustained exposure to IL-1, a proinflammatory agent, may also cause chondrocyte death.

These cultures undergo chondrocyte maturation with differentiation to hypertrophy and formation of cartilage modules.

Third, the inherent genetic variation in primary human chondrocyte cultures could bias the gene expression profile and lead to erroneous conclusions.

Hyaluronan is an important component of articular cartilage, where it is present as a coat around each cell (chondrocyte).

BMP4 and FGF2 have been experimentally shown to increase chondrocyte differentiation.

HIF-1 has been shown to be vital to chondrocyte survival, allowing the cells to adapt to low-oxygen conditions within the growth plates of bones.

In order to distinguish between these possibilities, we sought to employ cell culture assays with well-established parameters for chondrocyte differentiation and maturation.

The chondroblast is now a chondrocyte, which is usually inactive but can still secrete and degrade matrix depending on the conditions.

Dr. Walsh said: "Autologous chondrocyte implantation is just the beginning of where surgery is going in the next century.

Autologous Chondrocyte Implantation.