chondrocalcinosis

One genetic study found an association between chondrocalcinosis and a region of chromosome 8q.

Other diseases associated with chondrocalcinosis are Wilson's disease and osteoarthritis.

In some cases, traumatic arthritis can cause chondrocalcinosis.

Haemochromatosis arthropathy includes degenerative osteoarthritis and chondrocalcinosis.

Excessive calcium (due to hypomagnesemia) has a potential relationship with chondrocalcinosis, and magnesium supplementation may reduce or alleviate symptoms.

As with most conditions, chondrocalcinosis can present with similarity to other diseases such as ankylosing spondylitis and gout.

Hyperparathyroidism, hypothyroidism, hemochromatosis, hypophosphatemia, hypomagnesemia and renal osteodystrophy are often also associated with chondrocalcinosis.

In general, NSAIDs are administered in low doses to help prevent chondrocalcinosis.

The symptoms of familial articular chondrocalcinosis mimic those of classical gout and may include swelling, stiffness, and pain, usually in one joint.

Radiography has a large role to play in the diagnosis of chondrocalcinosis, with radiographs, CT scans, MRIs, ultrasound, and nuclear medicine all having a part.

Chondrocalcinosis occurs in a hereditary form (familial articular chondrocalcinosis), a form associated with metabolic disorders and a sporadic form.

Because any medication that could reduce the inflammation of chondrocalcinosis bears a risk of causing organ damage, treatment is not advised if the condition is not causing pain.

X-rays will also show bone features of renal osteodystropy (chondrocalcinosis at the knees and pubic symphysis, osteopenia and bone fractures) but may be difficult to differentiate from other conditions.

Radiographs may reveal pseudofractures in the lateral cortices of the proximal femora, stress fractures, and patients may experience osteopenia, chondrocalcinosis, features of pyrophosphate arthropathy, and calcific periarthritis.

Other rheumatological disorders that can cause the features typical for RS3PE include late onset (seronegative) rheumatoid arthritis, acute sarcoidosis, ankylosing spondylitis and other spondyloarthropathies such as psoriatic arthropathy, mixed connective tissue disease, chondrocalcinosis and arthropathy due to amyloidosis.