choline kinase

Choline Kinase requires magnesium ions (+2) as a cofactor for this reaction.

Choline Kinase catalyzes the formation of phoshocholine,the committed step in phosphatidylcholine biosynthesis.

Choline kinase beta is a protein encoded by the CHKB gene.

Ethanolamine kinase has no choline kinase activity and its activity is inhibited by ADP.

Choline kinase alpha is an enzyme that in humans is encoded by the CHKA gene.

Phosphocholine is made in a reaction, catalyzed by choline kinase, that converts ATP and choline into phosphocholine and ADP.

A related enzyme, ethanolamine kinase tends to co-purify with choline kinase leading to a suggestion that the two activities are mediated by two distinct active sites on a single protein.

Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine.

Although not much is known about the mechanism by which choline kinase reacts, the recent advancement in the elucidation of the structure of the enzyme has provided scientists with much more insight than they had previously.

Choline Kinase (also known as CK,ChoK and Choline Phosphokinase) is an enzyme which catalyzes the first reaction in the choline pathway for phosphatidylcholine (PC) biosynthesis.