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The globose nucleus is one of the deep cerebellar nuclei.
The whole cerebellum has only one output, which necessarily leads from the deep cerebellar nuclei.
Thus, the cerebellum communicates to the outside world via the cerebellar nuclei.
The cerebellum has four deep cerebellar nuclei embedded in the white matter in its center.
In deep cerebellar nuclei, calcium currents are not uniformly distributed along a dendrite.
The eight cerebellar nuclei, located within the deep white matter of each cerebellar hemisphere, are grouped into pairs.
These fibers form excitatory synapses with the granule cells and the cells of the deep cerebellar nuclei.
The cerebellar cortex projects to the deep cerebellar nuclei (the corticonuclear microcomplex).
The deep cerebellar nuclei have been shown to inhibit the inferior olive and this inhbition probably serves a negative feedback control function.
Neurons in the cerebellar nuclei generate spontaneous action potentials despite ongoing inhibition from Purkinje cells.
Most of the output from the cerebellum initially synapses onto the deep cerebellar nuclei before exiting via the three peduncles.
The Purkinje cells of the cerbellar cortex project into the deep cerebellar nuclei and inhibit the excitatory output system.
Ethanol has been shown to decrease levels of glutamate in the cerebellar nuclei which had been pre-treated with harmaline.
From lateral to medial, the four deep cerebellar nuclei are the dentate, emboliform, globose, and fastigii.
Other systems that may be involved in pattern generation and regulation are the pontine respiratory group, the lateral tegmental field and the deep cerebellar nuclei.
Dentate: The dentate nucleus is the largest, most lateral, and phylogenetically most recent of the cerebellar nuclei.
Interposed: The interposed nucleus is the smallest of the cerebellar nuclei, located between the denate and fastigial.
The deep cerebellar nuclei receive the final output from the cerebellar cortex via Purkinje cells in the form of inhibition.
Also, the Purkinje cells belonging to a microzone all send their axons to the same small cluster of output cells within the deep cerebellar nuclei.
Axons enter the cerebellum via the middle and inferior cerebellar peduncles, where some branch to make contact with deep cerebellar nuclei.
Inhibitory input is transmitted and received from various components of the cortex, including the cerebellar nucleus, a motor cortical cell and Purkinje cells.
Together, the deep cerebellar nuclei form a functional unit that provides feedback control of the cerebellar cortex by cerebellar output.
One exception is that fibers from the flocculonodular lobe synapse directly on vestibular nuclei without first passing through the deep cerebellar nuclei.
Other contributors include the vestibular nerve and nuclei, the spinal cord, the reticular formation, and feedback from deep cerebellar nuclei.
This input travels in two parts, to the surface of the cerebellar cortex as well as collateral input to the cerebellar nuclei.