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Induction of thyroid cell hyperplasia due to low levels of T4.
The stability of nodular endocrine cell hyperplasia in the previous studies is different from our findings.
In six patients the specimens still showed nodular argyrophil cell hyperplasia, and one patient had developed a carcinoid tumour.
The hypergastrinaemia and enterochromaffin like cell hyperplasia induced by these agents were abolished by antrectomy.
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia.
Squamous cell hyperplasia (formerly hyperplastic dystrophy).
Inappropriate insulin secretion secondary to islet cell hyperplasia, called pancreatic nesidioblastosis, might explain this syndrome.
In addition, gastrin acts as a trophic factor for parietal cells, causing parietal cell hyperplasia.
Multiple adenomas or diffuse islet cell hyperplasia commonly occurs; such tumors may arise from the small bowel rather than the pancreas.
The severity of argyrophil cell hyperplasia was assessed, based on the number of argyrophil cell clusters per mm.
Non-neoplastic vulvar disease includes lichen sclerosus, squamous cell hyperplasia, and vulvar vestibulitis.
In association with endocrine cell hyperplasia, gastric carcinoid tumours have been observed in 1-7% of pernicious anaemia patients screened by gastroscopy.
However, the term has been resurrected in recent years to describe a form of acquired hyperinsulinism with beta cell hyperplasia found in adults, especially after gastrointestinal surgery.
Moreover, they also showed that patients with pernicious anaemia and carcinoid tumours or nodular argyrophilic cell hyperplasia did not have the highest serum gastrin concentrations.
Results and discussion Results showed that all three cases spanned a morphologic spectrum ranging from columnar cell hyperplasia to ductal carcinoma in situ .
Thus, profound inhibition of acid secretion by omeprazole or histamine 2 receptor blockers in the rat led to endogenous hypergastrinaemia and enterochromaffin like cell hyperplasia.
Hypergastrinaemia is a recognised factor in the pathogenesis of DU as examplified by the Zollinger-Ellison syndrome and G cell hyperplasia.
In patients with sporadic type Zollinger-Ellison sydrome, in addition to a normal pattern of argyrophil cells (in 16%), cell hyperplasia was mainly diffuse (71%).
In patients with MEN 1 associated Zollinger-Ellison sydrome, howeve, diffuse and linear cell hyperplasia were roughly of the same order (53% and 47%, respectively).
In rats, the hypergastrinaemia induced by long term omeprazole has resulted in enterochromaffin-like (EC-like) cell hyperplasia and, subsequently, gastric carcinoid formation.
There may be basal cell hyperplasia (increased numbers of basal cells), and they may lose their cellular orientation (losing their polarity and long axis)
Histological changes consist of epithelial necrosis and detachment, increase in the area of smooth muscle, epithelial regeneration and mucous cell hyperplasia.
A study of PDE4 inhibition in a murine model of allergic asthma showed that piclamilast significantly improves the pulmonary function, airway inflammation and goblet cell hyperplasia.
Inactivating mutation of glucagon receptor in humans causes resistance to glucagon and is associated with pancreatic alpha cell hyperplasia, nesidioblastosis, hyperglucagonemia, and pancreatic neuroendocrine tumors.