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Therefore, these lengths can be used as signatures to identify members of a B cell clone.
Many unique B cell clones may be able to bind to the individual epitopes.
Thus fetal cell clones are provided with long telomeres and gain a "fresh start."
Thus, approximately 10 different epitopes can be recognized by all the B cell clones combined.
This diminishes both B cell clone expansion and antibody synthesis.
For each T cell clone, percent cytotoxicity was plotted against peptide concentration.
Single cell clones were generated by limiting dilution.
It appears then, that men, lacking the specific ovarian self-antigen, fail to provide positive selection for these pre-B cells clones.
Recognition by a naive T cell clone of its cognate antigen results in the initiation of an immune response.
Multiple myeloma is a cancer of the blood, characterized by accumulation of a plasma cell clone in the bone marrow.
As a result, the immune system produces millions of cell clones, each capable of producing a unique variety of antibody.
The result is proliferation of a plasma cell clone and genomic instability that leads to further mutations and translocations.
Type Ap spermatogonia repeatedly divide mitotically to produce identical cell clones linked by cytoplasmic bridges.
Analogues which compete for antigen binding to an arsonate-reactive T cell clone inhibit the functional response to arsonate.
The possibility exists, then, for variability within amino acid sequence, but similarity in three-dimensional structure between two peptides can be recognized by T cell clones.
Moreover, selection of resistant cell clones requires only minimal levels of Neo gene expression [ 53 ] .
Targeted ES cell clones were injected into C57Bl/6J blastocysts and chimeras obtained.
Cell clones could then be isolated by their resistance to ganciclovir due to loss of the HSV-tk gene, i.e. ("negative selection").
Just as in T cells, clonal deletion and clonal anergy can physically eliminate autoreactive B cell clones.
A pathogen may contain a protein that acts as a mitogen to encourage cell division, thus causing more B or T cell clones to be produced.
DKFZ): Study of U937 promonocytic cell clones selected for their resistance to parvovirus H-1 infection.
These data confirm that this selection strategy is extremely efficient in identifying ES cell clones containing correctly targeted transgenes [ 2 ] .
After a minimum of 30 days culture, single cell clones were isolated by limiting dilution in 96 well culture clusters, in the presence of ethidium bromide.
Astaxathin, a carotenoid without vitamin A activity, augments antibody responses in cultures including T-helper cell clones and suboptimal doses of antigen.
Following this method, upward of 90% of HAT resistant ES cell clones contain correctly targeted transgenes [ 2 ] .