Zebra-tailed lizards (Callisaurus) are a genus of phrynosomatid lizards endemic to the southwestern United States and northwestern Mexico.

The zebra-tailed lizard is common and widely distributed throughout the southwestern United States, ranging from the Mojave and Colorado deserts north into the southern Great Basin.

They become darker when burrowing and lighter when basking - both the desert iguana and the zebra-tailed lizard become so pale that they appear to shine due to the amount of light they reflect.

The genus Callisaurus is monotypic, containing only one species, Callisaurus draconoides.