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Bronchodilatory response is defined as the mean time to achieve improvement in lung function.
The bronchodilatory and expectorant properties of the leaves are attributed to vasicine.
It shows bronchodilatory activity in vitro but bronchoconstrictory activity in vivo.
"The studies confirm the bronchodilatory effect of aclidinium at the dose tested, although the magnitude was lower than seen in previous studies.
Bronchodilatory response rate was investigated in two identically designed, multicenter, single-dose, four-period crossover studies.
This leads to a reduction in smooth muscle contraction and mucus secretion and thus produces a bronchodilatory effect.
Both the alkaloids in combination (1:1) showed pronounced bronchodilatory activity in vivo and in vitro.
In addition, these data demonstrated that SYMBICORT provided a similar bronchodilatory response to albuterol.
N30-201 is a proprietary nebulized formulation of s-nitrosoglutathione (GSNO), an endogenous bronchodilatory molecule that serves as a crucial store of nitric oxide (NO) bioactivity in the human airway.
Findings of a phase I single-dose study, also presented at ERS 2007, demonstrate the bronchodilatory effects of aclidinium.(2) In the phase I study, in 12 healthy volunteers, bronchoconstriction was induced with methacholine challenge and then treated with one of three doses of aclidinium.
In both studies, bronchodilatory response was measured by the mean improvements in forced expiratory volume in one second (FEV1) - how much air a person can exhale during a forced breath in the first second of exhalation, which is a measure of airway function and can be reduced with airway obstruction.