bone spicule

The first step in the process is the formation of bone spicules which eventually fuse with each other and become trabeculae.

These aggregates of bony matrix are called bone spicules.

During the formation of bone spicules, cytoplasmic processes from osteoblasts interconnect.

Since bone spicules tend to form around blood vessels, the perivascular space is greatly reduced as the bone continues to grow.

Symptoms of RP include loss of sensitivity to dim light, abnormal visual function, and characteristic bone spicule deposits of pigment in the retina.

In conclusion, as regards setting the tolerance thresholds for adventitious presence of bone spicules and technically unavoidable contamination, it is imperative that we apply scientific rigour through standing committees under the comitology procedure.