blood-testis barrier

Spermatozoa are protected from the male's immune system by the blood-testis barrier.

The blood-testis barrier separates the immune system and the developing spermatozoa.

If prevalence was the case, the infectious proteins would then have to cross the blood-testis barrier to make transmission possible.

It is able to cross the blood-testis barrier and blood-brain barrier.

The function of the blood-testis barrier (red highlight in diagram above) may be to prevent an auto-immune reaction.

The blood-testis barrier is also important in preventing toxic substances from disrupting spermatogenesis.

The tight junction between the Sertoli cells form the blood-testis barrier but it is usually breached by physiological leakage.

The blood-testis barrier is a physical barrier between the blood vessels and the seminiferous tubules of the animal testes.

Follicle stimulating hormone stimulates both the production of androgen binding protein by Sertoli cells, and the formation of the blood-testis barrier.

ICAM-1 and soluble ICAM-1 have antagonistic effects on the tight junctions forming the blood-testis barrier, thus playing a major role in spermatogenesis.

A physiologic blood-testis barrier seems to appear, and there is a higher incidence (approximately 50%) of residual cancer in the testicle than in remaining radiographically detectable retroperitoneal masses after platinum-based chemotherapy.

The tight junctions of Sertoli cells form the blood-testis barrier, a structure that partitions the interstitial blood compartment of the testis from the adluminal compartment of the seminiferous tubules.

Pgp is extensively distributed and expressed in the intestinal epithelium, hepatocytes, renal proximal tubular cells, adrenal gland and capillary endothelial cells comprising the blood-brain and blood-testis barrier.

Because of the apical progression of the spermatogonia, the tight junctions must be dynamically reformed and broken to allow the immunoidentical spermatogonia to cross through the blood-testis barrier so they can become immunologically unique.

The blood-testis barrier, maintained by the tight junctions between the Sertoli cells of the seminiferous tubules, prevents communication between the forming spermatozoa in the testis and the blood vessels (and immune cells circulating within them) within the interstitial space.

Reproductive immunology refers to a field of medicine that studies interactions (or the absence of them) between the immune system and components related to the reproductive system, such as maternal immune tolerance towards the fetus, or immunological interactions across the blood-testis barrier.

The name "blood-testis barrier" is misleading in that it is not a blood-organ barrier in a strict sense, but is formed between Sertoli cells of the seminiferous tubule and as such isolates the further developed stages of germ cells from the blood.

However, it is believed in the field of testicular immunology that the blood-testis barrier cannot account for all immune suppression in the testis, due to (1) its incompleteness at a region called the rete testis and (2) the presence of immunogenic molecules outside the blood-testis barrier, on the surface of spermatogonia.