blocking antibody

Researchers then devised a therapy to induce women to make the blocking antibodies.

Cells were pretreated for 30min with blocking antibodies.

Parietal cell and intrinsic factor blocking antibodies were not detected in any subject with atrophy.

PD-L1 blockade (using blocking antibodies) resulted in increased mortality for infected mice.

Blocking antibodies have been described as a mechanism for HSV-1 to evade the immune system.

Dr. Loveless also discovered blocking antibodies for sufferers of pollen allergies and hay fever.

Additionally, CD47 blocking antibodies inhibit proliferation of unstimulated astrocytoma cells but not normal astrocytes.

The biological corollary of this is that blocking antibodies against ICAM-1 have been shown effectively to prevent allograft rejection.

'Foreign' Tissue Dr. Beer said blocking antibodies are highly specific, protecting only the pregnancy and not interfering with any of the mother's other immune responses.

These "blocking antibodies" are a unique feature of pregnancy, said Dr. Bruce Smith of Jefferson Medical College.

Immunotherapy is still in its infancy for combating this allergy, but Dr. Kang has had some encouraging results producing blocking antibodies and reducing sensitivity.

Perhaps the blocking antibodies are all-important and can cope with the increased antigenic differences in hybrids, but this is only a speculation, and more work needs to be done.

Activating and blocking antibodies mostly bind to conformational epitopes, whereas neutral antibodies bind to linear epitopes.

In more than 80 percent of cases, Dr. Beer has reported, the injections stimulate the release of enough blocking antibodies to permit a normal pregnancy and live birth.

A blocking antibody is an antibody that does not have a reaction when combined with an antigen, but prevents other antibodies from combining with that antigen.

"Blocking antibodies create a cloak of disguise and the fetus becomes a wolf in sheep's clothing as far as the mother's immune system is concerned," Dr. Beer said.

These antibodies, called blocking antibodies, keep the mother's immune system from recognizing the fetus as foreign and rejecting it as if it were a transplant of foreign tissue.

Since half the genetic information in the fetus comes from a "foreigner," namely the father, without blocking antibodies acting as an immunological fortress, the mother's body would launch an attack against it.

Furthermore, she explained in an interview, some women miscarry even though they can make blocking antibodies, but they are able to deliver live babies through the protection offered by gamma globulin.

The role of CD47 in cell migration was first demonstrated for neutrophils, where CD47 blocking antibodies inhibited transmigration of neutrophils and monocytes through the endothelium.

Proliferation of SK-N-BE cells could be suppressed by the pre-incubation of cells with anti-TNFR2 blocking antibodies without concomitant cytotoxicity (data not shown).

Although these blocking antibodies may be confined to one of the larger muscles responsible for moving the face or appendages or for breathing, about 90% of MG patients eventually have eye involvement.

Inhibition of Aurora B function by RNA interference or microinjection of blocking antibodies impairs the alignment of chromosomes at the equator of the mitotic spindle.

The diagnosis of MG can also be confirmed with blood work that measures the amount of blocking antibody present, but only 70% of ocular MG patients have detectable antibody levels.