bioorthogonal chemistry

The use of bioorthogonal chemistry typically proceeds in two steps.

Pharmacokinetics are a growing concern as bioorthogonal chemistry expands to live animal models.

The reaction has been widely used in bioorthogonal chemistry and in organic synthesis.

The term bioorthogonal chemistry refers to any chemical reaction that can occur inside of living systems without interfering with native biochemical processes.

It launched the field of bioorthogonal chemistry as the first reaction with completely abiotic functional groups although it is no longer as widely used.

Thus, chemists have recently developed a panel of bioorthogonal chemistry that proceed chemospecifically, despite the milieu of distracting reactive materials in vivo.

Bertozzi is credited for developing the field of bioorthogonal chemistry which employs a bioorthogonal chemical reporters, such as the azide to label biomolecules within living systems.

Although the reaction produces a regioisomeric mixture of triazoles, the lack of regioselectivity in the reaction is not a major concern for its applications in bioorthogonal chemistry.

Despite long being considered to be chemical curiosities with limited synthetic applications, recent work has demonstrated the utility of strained cycloalkynes in both total synthesis of complex natural products and bioorthogonal chemistry.

Jennifer Prescher & Carolyn R. Bertozzi, the developers of bioorthogonal chemistry, defined bioorthogonal chemical reporters as "non-native, non-perturbing chemical handles that can be modified in living systems through highly selective reactions with exogenously delivered probes."