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The first sign of porous silicon as a bioactive material was found in 1995.
In recent years, two discoveries have yielded bioactive materials with more advanced structures and potential applications.
These bioactive materials stimulate bone formation leading to a physico-chemical bond.
Quebrachitol is a versatile building block in the construction of naturally occurring bioactive materials.
In 1973 it was proved for first time that polyester degrades when disposed in bioactive material such as soil.
Bioactive retention can be achieved in cases where the implant is coated with bioactive materials such as hydroxyapatite.
Taking this a step further, implantable devices can be coated with a bioactive material to encourage adsorption of specific proteins, fibrous capsule formation, and wound healing.
Therefore, the apatite formation on the surface of biomaterials, soaked in the SBF solution, is considered a successful development of novel bioactive materials.
SMEDDS offer numerous advantages: spontaneous formation, ease of manufacture, thermodynamic stability, and improved solubilization of bioactive materials.
Research involves candidates for functional food ingredients by examining the efficacy of novel bioactive materials such as plant sterols - natural components found in plants which can act as cholesterol-lowering agents.
Protein surface modification of various types biomaterials (ceramics, polymers, metals, composites) is performed to ultimately increase biocompatibility of the material and interact as a bioactive material for specific applications.
Surface functionalization may provide a way to transform a bio-inert material into a biomimetic or even bioactive material by coupling of protein layers to the surface, or coating the surface with self-assembling peptide scaffolds to lend bioactivity and/or cell attachment 3-D matrix.
These molecules have revolutionized the field of bioactive materials for regenerative medicine, with potential applications in bone and cartilage regeneration, angiogenesis for ischemia or peripheral artery disease, cancer therapy, novel therapies for neurodegenerative diseases, stem cell differentiation, spinal cord injury, diabetes, and many other areas.