bilirubin encephalopathy

Prolonged hyperbilirubinemia (severe jaundice) can result into chronic bilirubin encephalopathy (kernicterus).

Before the availability of phototherapy, these children died of kernicterus (bilirubin encephalopathy) or survived until early adulthood with clear neurological impairment.

Pathogenesis of bilirubin encephalopathy involves several factors, including the transport of bilirubin across the blood-brain barrier and into neurons.

Acute Bilirubin Encephalopathy (ABE)

Chronic Bilirubin Encephalopathy (CBE)

Subtle Bilirubin Encephalopathy (SBE)

Lesions to this region principally arise via hypoxic ischemic brain injury (HIBI) or bilirubin encephalopathy.

Bilirubin Encephalopathy None Kernicterus is a rare neurological disorder characterized by excessive levels of bilirubin in the blood (hyperbilirubinemia) during infancy.

Neonates are especially vulnerable to bilirubin levels due to an immature blood-brain barrier that predisposed them to kernicterus / bilirubin encephalopathy which can result in permanent neurological damage.

Chronic bilirubin encephalopathy, which can result from erythroblastosis fetalis, is a disease which has numerous effects on an infant, but it can also cause enamel hypoplasia and green staining of enamel.eMedicine:

Athetoid/ dyskinetic cerebral palsy (ADCP) is a movement disorder primarily associated with damage to the basal ganglia, in the form of lesions that occur during brain development due to bilirubin encephalopathy and hypoxic-ischemic brain injury.