beta-2-microglobulin

Beta-2-microglobulin is a protein found on the surface of plasma cells.

Beta-2-microglobulin and albumin are found in the blood.

Beta-2-microglobulin is elevated in proportion to tumor mass.

The stage of multiple myeloma is based on the levels of beta-2-microglobulin and albumin in the blood.

For multiple myeloma, beta-2-microglobulin, M protein, and other proteins made by the myeloma cells are measured.

In stage III multiple myeloma, the blood level of beta-2-microglobulin is 5.5 g/mL or higher.

High levels of serum LDH and beta-2-microglobulin.

Because beta-2-microglobulin is a large molecule, with a molecular weight of about 11,600 daltons, it does not pass at all through low-flux dialysis membranes.

Some larger molecules, such as beta-2-microglobulin, are not removed at all with low-flux dialyzers; lately, the trend has been to use high-flux dialyzers.

Transgenic rats that express human HLA-B27 and Beta-2-microglobulin have developed spontaneous inflammatory disease in the gastrointestinal tract.

Di Giovanni S, Valentini G, Carducci P, et al.: Beta-2-microglobulin is a reliable tumor marker in chronic lymphocytic leukemia.

Chronowski GM, Wilder RB, Tucker SL, et al.: An elevated serum beta-2-microglobulin level is an adverse prognostic factor for overall survival in patients with early-stage Hodgkin disease.