basophilia

Basophilia is also uncommon but may be seen in some forms of leukaemia or lymphoma.

Minimal absolute basophilia with basophils accounting for less than 2% of white blood cells.

Basophilia as an isolated finding is uncommon.

Minimal basophilia may be present.

Basophilia is a condition where the basophil quantity is abnormally elevated (more than 10 basophils per liter of blood).

Necrobiosis is defined as the physiological death of a cell, and can be caused by certain conditions such as basophilia, erythema or the presence of a tumor.

Basophilic stippling aka Punctate basophilia refers to an observation found when observing a blood smear in which erythrocytes display small dots at the periphery.

Döhle bodies, cytoplasmic basophilia and cytoplasmic granulation all reflect "defects" in cell production and maturation during active granulocytopoiesis.

Historically, various clues including the leukocyte alkaline phosphatase score and the presence of basophilia were used to distinguish CML from a leukemoid reaction.

It is a good fixative for connective tissue, preserves glycogen well, and extracts lipids to give superior results to formaldehyde in immunostaining of biogenic and polypeptide hormones However, it causes a loss of basophilia unless the specimen is thoroughly washed following fixation.

The differential diagnosis includes: blast crisis of CML, other AML subtypes with basophilia such as AML with maturation (M2) associated with abnormalities of 12p or t(6;9), acute eosinophilic leukemia, and, rarely, a subtype of ALL with prominent coarse granules.