It was a blow, Baron - the worst setback in my whole campaign.
Probably the worst setback to upper-class eating in recent years is the practice of serving caviar on pastry.
It was the worst setback of the war for the Kingdom.
We here can give them no worse setback than striking it from their grasp.
For the Rangers, it stood to be among the worst potential setbacks conceivable.
They suffered a particularly bad setback in the 1990s.
One year later, however, the team suffered its worst setback in years.
The stock market was sinking fast, headed toward its worst setback since 1990.
This was the time of their worst setbacks.
The Dow lost 192 points that day in its worst setback of the year.