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Effect of oral supplementation of lactobacilli on bacterial translocation in acute liver injury induced by D-galactosamine.
The bacterial translocation channel is formed by a trimeric protein complex called SecYEG.
Gastrointestinal: hemorrhage (ulcer), dysmotility, pneumoperitoneum, bacterial translocation.
L. reuteri greatly mitigates the symptoms of methotrexate-induced enterocolitis in rats, one of which is bacterial translocation.
Similarly, as the gut requires luminal nutritional support to prevent mucosal atrophy and subsequent bacterial translocation the use of parenteral rather than enteral nutrition may also increase the likelihood of infection.
In rodent studies, L. reuteri was found to greatly reduce the amount of bacterial translocation following either the surgical removal of the liver or injection with D-galactosamine, a chemical which also causes liver damage.