autoagglutination

A slide coagulase test is run with a negative control to rule out autoagglutination.

Clumping in both drops is an indication of autoagglutination, so a tube test should be carried out.

The head domain is very important for attachment to the host cell and for autoagglutination, sticking to itself.

Autoagglutination can result in visible clumping of erythrocytes in the collection device.

French investigators led by Chauffard stressed the importance of red-cell autoagglutination in patients with acquired hemolytic anemia.

Autoagglutination is seen to occur in a type of immune mediated hemolytic anemia known as "cold antibody hemolytic anemia".

Autoagglutination should also be distinguished from "Rouleaux formation" wherein normal blood tends to form stacks on keeping, which disperses on dilution with normal saline.

Particularly in the case of certain Yersinia spp., the TAA YadA has a role in autoagglutination, serum resistance, complement inactivation and phagocytosis resistance.

Diagnosis of autoagglutination can be confirmed by a positive "Direct Antiglobulin Test" aka Direct Coomb's test using Coomb's serum (positivity is seen in 75% of cases)

Autoagglutination represents clumping of an individual's red blood cells (RBCs or erythrocytes) by his or her own serum due to the RBCs being coated on their surface by antibodies.