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Those interviewed favoured a case finding approach rather than true screening, i.e. the identification of asymptomatic disease.
The clinical course generally varies and ranges from asymptomatic disease to a debilitating chronic condition that may lead to death.
Asymptomatic disease is typically not treated.
Several studies suggest the presentation in people of African origin may be more severe and disseminated than for Caucasians, who are more likely to have asymptomatic disease.
First-degree relatives of people with thoracic aortic aneurysm or dissection should have aortic imaging to identify asymptomatic disease.
Glaucoma, generally speaking, is an asymptomatic disease affecting 4 percent of the population older than 40, and it is a leading cause of legal blindness in this country.
Another remarked that the "extent of asymptomatic disease in this series would suggest the true prevalence of LS in men might be much higher than published work suggests."
Given the indolent course of the disease in pediatric patients, it is reasonable to withhold extensive and mutilative surgeries and carefully observe children with locally recurrent or unresectable asymptomatic disease.
Failure of neurologic, cardiac, renal, and gastrointestinal (GI) organs, as well as death, can occur unpredictably at any time, either very quickly or following prolonged symptomatic or asymptomatic disease progression.
Infection in newborn children, although common, is often associated with mild or asymptomatic disease; the most severe symptoms tend to occur in children six months to two years of age, the elderly, and those with compromised or absent immune system functions.