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He developed the profound arterial hypotension technique to make open aneurysmal surgery in a safer way.
In hypersensitivity: muscle weakness, headache, arterial hypotension, nausea, vomiting, dyspepsia.
They may respond by sending signals that trigger paradoxical bradycardia and decreased contractility, resulting in additional and relatively sudden arterial hypotension.
Eight patients were in septic shock, defined as the presence of an identified infectious foci associated with arterial hypotension requiring the continuous intravenous administration of norepinephrine [ 16].
The resultant arterial hypotension is sensed in the carotid sinus baroreceptors, and efferent fibers from these receptors trigger autonomic signals that increase cardiac rate and contractility.
Rare side effects include flushing of the face, hyperhidrosis (excessive sweating), cutaneous eruption, arterial hypotension, tachycardia, loss of appetite, jaundice, eosinophilia, thrombopenia, mixed hepatitis, headache, allergic reaction, chronic active hepatitis, and paradoxical aggravation of cerebral vasospasm.
While these factors predispose a patient to develop NAION, the most common precipitating factor is marked fall of blood pressure during sleep (nocturnal arterial hypotension)- that is why at least 75% of the patients first discover visual loss first on waking from sleep.