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"Some- body must have developed that apoenzyme.
However, the apoenzyme without copper is unstable.
An apoenzyme together with its cofactor(s) is called a holoenzyme (this is the active form).
Crystallographic studies have helped elucidate the apoenzyme structure of phosphopentose epimerase.
This protein has also been used in fluorescent sensing either simply as an apoenzyme or as an as a holoenzyme.
An apoenzyme (or, generally, an apoprotein) is the protein without any small-molecule cofactors, substrates, or inhibitors bound.
Neurological symptoms are most likely due to diminished affinity of pyridoxine for the apoenzyme, which can only be overcome by increasing tissue concentrations of the enzyme.
An inactive enzyme, without the cofactor is called an apoenzyme, while the complete enzyme with cofactor is the holoenzyme.
This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme.