antagonistic pleiotropy

Based on antagonistic pleiotropy, Rose expected that this would surely reduce their fertility.

This is an example of antagonistic pleiotropy being an explanation for senescence.

Williams (1957) proposed his own theory, called antagonistic pleiotropy.

In antagonistic pleiotropy, genes carry effects that are both beneficial and detrimental.

Antagonistic pleiotropy has been identified both in model organisms and in humans.

In antagonistic pleiotropy, one of these effects is beneficial and another is detrimental.

Such genetic effects are called antagonistic pleiotropy.

Antagonistic pleiotropy is one of the several reasons evolutionary biologists give for organisms never being able to reach perfection through natural selection.

Still, antagonistic pleiotropy has some evolutionary benefits.

Rose's laboratory has conducted the longest-running artificial selection experiment designed to test the theory of antagonistic pleiotropy.

The prediction of the antagonistic pleiotropy hypothesis was that these long-lived flies would have much lower fertility early in life.

Antagonistic pleiotropy has several negative consequences.

The central hypothesis of antagonistic pleiotropy remains the prevailing evolutionary explanation of senescence.

Another evolutionary theory of aging was proposed by George C. Williams and involves antagonistic pleiotropy.

The long-lived flies show other weaknesses that would make them poor competitors in the wild, and perhaps these traits are the true areas of antagonistic pleiotropy.

Antagonistic pleiotropy is a prevailing theory today, but this is largely by default, and not because the theory has been well verified.

Antagonistic pleiotropy refers to the expression of a gene resulting in multiple competing effects, some beneficial but others detrimental to the organism.

The antagonistic pleiotropy hypothesis was first proposed by George C. Williams in 1957 as an evolutionary explanation for senescence.

This suggests a role for antagonistic pleiotropy, whereby a deleterious mutation is preserved in a population because it still confers some survival benefit.

Antagonistic pleiotropy is a theory proposed as an alternative by George C. Williams, a critic of Medawar, in 1957.

The survival of many serious genetic disorders in our long evolutionary history has led researchers to reassess the role of antagonistic pleiotropy in disease.

Sickle cell anemia, Beta-thalassemia, and cystic fibrosis are some other examples of the role antagonistic pleiotropy may play in genetic disorders.

The phenomenon was first described by George C. Williams in 1957, but it was Rose who coined the phrase "antagonistic pleiotropy".

Another instance of antagonistic pleiotropy is manifested in Huntington's disease, a rare neurodegenerative disorder characterized by a high number of CAG repeats within the Huntingtin gene.

The disposable soma theory and antagonistic pleiotropy theory are examples in which a compensating individual benefit, compatible with classical evolution theory (See neo-Darwinism and modern evolutionary synthesis) is proposed.