analgetic

Lefetamine was invented in the 1940s and showed weak analgetic activity.

Antispasmodic and analgetic properties have been described.

"Resolution reveals that the analgetic activity in this case resides almost entirely in the (+) isomer."

The analgetic potency is about the same as of pethidine (meperidine), the antagonistic effect is 1/50 of Nalorphine.

The l-isomere showed weak analgetic action comparable to codeine and antitussive action far weaker than codeine.

For example, it is a building block in the preparation of the antibiotic linezolid, the anticancer agent gefitinib (Iressa) and the analgetic dextromoramide.

Some related pyrrylphenylethanones had analgetic activity comparable to morphine Some pyrrole analogues were reported to have analgetic effects comparable to lefetamine and being devoid of neurotoxic properties.