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Amebic colitis.
Tumor necrosis factor-α is a key mediator of the gut inflammation seen in amebic colitis in human intestine in the SCID mouse-human intestinal xenograft model of disease.
Expression of amoebapores is required for full expression of Entamoeba histolytica virulence in amebic liver abscess, but is not necessary for the induction of inflammation or tissue damage in amebic colitis.
Invasion of the intestinal lining causes amoebic dysentery or amoebic colitis.