alpha-mannosidosis

Alpha-mannosidosis belongs to a group of diseases known as the lysosomal storage disorders.

The life expectancy in Alpha-mannosidosis is highly variable.

A deficiency can lead to alpha-mannosidosis.

There is no cure for congenital Alpha-Mannosidosis.

Alpha-mannosidosis is caused by mutations of the MAN2B1 gene.

A milder form of Alpha-mannosidosis involves mild to moderate mental retardation which develops during childhood or adolescence.

Alpha-Mannosidosis is classified into types I through III based on severity and age of onset.

Alpha-mannosidosis is a lysosomal storage disorder caused by deficient activity of the enzyme alpha-D-mannosidase (see Alpha-Mannosidase).

Defects in the gene cause lysosomal alpha-mannosidosis (AM), a lysosomal storage disease characterised by the accumulation of unbranched oligo-saccharide chains.