allelic imbalance

High density SNP arrays help scientists identify patterns of allelic imbalance.

Copy-neutral LOH is a form of allelic imbalance.

MIP, for instance, can be used to capture targets for SNPgenotyping, copy number variation or allelic imbalance studies, to name a few.

While these CGMA-predicted regions were near the 35% cutoff for detection, they could represent other regions of allelic imbalance yet to be detected by CGH.

Verhage BA, van Houwelingen K, Ruijter TE, et al.: Allelic imbalance in hereditary and sporadic prostate cancer.

A computational technique termed comparative genomic microarray analysis (CGMA) has previously been used to identify regions of allelic imbalance indirectly from gene-expression profiles of human tumors [ 8].

Hamann U, Herbold C, Costa S, et al.: Allelic imbalance on chromosome 13q: evidence for the involvement of BRCA2 and RB1 in sporadic breast cancer.

Studies of the hamartomatous polyps and cancers of PJS show allelic imbalance (loss of heterozygosity [LOH]) consistent with the two-hit hypothesis, demonstrating that STK11 is a tumor suppressor gene.

Wang ZJ, Ellis I, Zauber P, et al.: Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence.