allelic exclusion

At least two distinct selection events can lead to allelic exclusion.

Though the mechanism by which allelic exclusion occurs is not fully understood.

A recent study showed that Cp A-methylation helps for allelic exclusion in sensory neurons.

Lack of TCRalpha allelic exclusion.

Allelic exclusion is a process by which only one allele of a gene is expressed while the other allele is silenced.

Allelic exclusion has been observed most often in genes for cell surface receptors and has been extensively studied in immune cells such as B lymphocytes.

Pre-TCR-mediated feedback on TCRbeta rearrangement as essential mechanism for TCRbeta allelic exclusion.

As a result of allelic exclusion, all the antigen receptors on an individual lymphocyte will have the same amino acid sequence in the variable domain of the heavy chain protein.

After a B cell produces a functional immunoglobulin gene during V(D)J recombination, it cannot express any other variable region (a process known as allelic exclusion) thus each B cell can produce antibodies containing only one kind of variable chain.