alkaline tide

Thus, alkaline tide is self-limited and normally lasts less than two hours.

The test relies on the capacity of the kidney to retain H + during gastric acid secretion, leading to a postprandial urine 'alkaline tide'.

A more pronounced alkaline tide results from vomiting, which stimulates hyperactivity of gastric parietal cells to replace lost stomach acid (verification needed).

The parietal cell releases bicarbonate into the blood stream in the process, which causes a temporary rise of pH in the blood, known as alkaline tide.

Measurement of the urine alkaline tide as an index of gastric acid output, has been proposed as a non-invasive alternative to conventional gastric secretion studies.

Excess bicarbonate is excreted by the kidney, which means that a transient rise in urine bicarbonate excretion (the urine 'alkaline tide') immediately follows maximal gastric acid secretion.

Furthermore, the sudden increase in gastric acid secretion following a meal can cause a physiological phenomenon called an alkaline tide, which is due to the production and export of bicarbonate from parietal cells.

Post-prandial (i.e., after a meal) alkaline tide lasts until the acids in food absorbed in the small intestine reunite with the bicarbonate that was produced when the food was in the stomach.

The bicarbonate ion (HCO) is exchanged for a chloride ion (Cl) on the basal side of the cell and the bicarbonate diffuses into the venous blood, leading to an alkaline tide.

After stimulation of HCl secretion by histamine, Cl -/HCO 3 -exchange across the basolateral membrane increases several fold; the HCO 3 -efflux represents the blood 'alkaline tide.'

Combined with the resulting alkaline tide, this leads to hypochloremic metabolic alkalosis (low chloride levels together with high HCO and CO and increased blood pH) and often hypokalemia (potassium depletion).

Alkaline tide refers to a condition, normally encountered after eating a meal, where during the production of HCl by parietal cells in the stomach, the parietal cells also secrete bicarbonate ions across their basolateral membranes and into the interstitial fluid, causing a temporary increase in pH.

The alkaline tide is neutralized by the action of the pancreatic duct which produces a bicarbonate secretion that is deposited into the lumen of the duct while the byproduct, hydrogen ions, are pumped out the basal membrane into the portal blood stream, thereby neutralizing the bicarbonate from the stomach.