adrenocortical carcinoma
adrenal cortical carcinoma
adrenal cortex cancer

Adrenocortical carcinoma is rare, with only about 150 cases a year.

There are different types of treatment for patients with adrenocortical carcinoma.

These and other symptoms may be caused by adrenocortical carcinoma.

Adrenocortical carcinoma may be cured if treated at an early stage.

Having certain genetic conditions increases the risk of developing adrenocortical carcinoma.

Possible signs of adrenocortical carcinoma include pain in the abdomen and certain physical changes.

Treatment of stage I adrenocortical carcinoma is usually surgery (adrenalectomy).

Adrenocortical carcinoma may present differently in children and adults.

Adrenocortical carcinoma is also called cancer of the adrenal cortex.

Adrenocortical carcinoma is a rare tumor that affects only 1 to 2 persons per one million population.

Adrenocortical carcinoma may be linked to a cancer syndrome that is passed down through families (inherited).

Adrenocortical carcinoma is a rare tumor, with incidence of 1-2 per million population annually.

A higher than normal amount of these hormones that may be a sign of adrenocortical carcinoma.

Risk factors for adrenocortical carcinoma include having the following hereditary diseases:

The tests and procedures used to diagnose adrenocortical carcinoma depend on the patient's symptoms.

Adrenocortical carcinoma is most common in children younger than 5 and adults in their 30s and 40s.

Due to their location deep in the retroperitoneum, most adrenocortical carcinomas are not diagnosed until they have grown quite large.

Other tumours seen in this syndrome include leukaemia, lymphoma and adrenocortical carcinoma.

The following stages are used for adrenocortical carcinoma:

Mitotane may be used to treat adrenocortical carcinoma.

Adrenocortical carcinoma may not improve with chemotherapy.

Treatment of stage III adrenocortical carcinoma may include the following:

Hormonal: Approximately 60% of adrenocortical carcinomas produce hormones.

Complete surgical removal of the tumor is the treatment of choice for patients with stage I adrenocortical carcinomas.

This can result in expensive additional testing and invasive procedures to rule out the slight possibility of an early adrenocortical carcinoma.

There is also a loss of activity of the p57 gene product in virilizing adenomas and adrenal cortical carcinomas.

Percarpio B, Knowlton AH: Radiation therapy of adrenal cortical carcinoma.

In contrast, IGF-II gene expression has been shown to be high in adrenal cortical carcinomas.

Wooten MD, King DK: Adrenal cortical carcinoma.

Expression of the h19 gene is markedly reduced in both nonfunctioning and functioning adrenal cortical carcinomas, especially in tumors producing cortisol and aldosterone.

Nader S, Hickey RC, Sellin RV, et al.: Adrenal cortical carcinoma.

Lubitz JA, Freeman L, Okun R: Mitotane use in inoperable adrenal cortical carcinoma.

Chun HG, Yagoda A, Kemeny N, et al.: Cisplatin for adrenal cortical carcinoma.

Schlumberger M, Ostronoff M, Bellaiche M, et al.: 5-Fluorouracil, doxorubicin, and cisplatin regimen in adrenal cortical carcinoma.

Haq MM, Legha SS, Samaan NA, et al.: Cytotoxic chemotherapy in adrenal cortical carcinoma.

Camuto P, Schinella R, Gilchrist K, et al.: Adrenal cortical carcinoma: flow cytometric study of 22 cases, an ECOG study.

Lee JE, Berger DH, el-Naggar AK, et al.: Surgical management, DNA content, and patient survival in adrenal cortical carcinoma.

Wagner AS, Fleitz JM, Kleinschmidt-Demasters BK: Pediatric adrenal cortical carcinoma: brain metastases and relationship to NF-1, case reports and review of the literature.

Adrenocortical carcinoma, also adrenal cortical carcinoma (ACC) and adrenal cortex cancer, is an aggressive cancer originating in the cortex (steroid hormone-producing tissue) of the adrenal gland.

In 1995, at the age of seven, daughter Michelle was diagnosed with adrenal cortical carcinoma, a condition traced to a genetic tendency called Li-Fraumeni syndrome; after painful and intensive treatment she died in December 1996.

Research Fellow Sachin H. Jain, Professor Michael E. Porter, and colleagues at Harvard Business School have published an extensive business school case study documenting the care process for a single patient with adrenal cortical carcinoma, "Ledina Lushko: Navigating Health Care Delivery."

Indeed, persons with Li-Fraumeni syndrome have an approximately 25-fold increased risk of developing a malignant tumor by age 50 than the population average, and are at risk for a wide range of malignancies, with particularly high occurrences of breast cancer, brain tumors, acute leukemia, soft tissue sarcomas, bone sarcomas, and adrenal cortical carcinoma.

There are several relatively rare variants of adrenal cortical carcinoma: Oncocytic adrenal cortical carcinoma, Myxoid adrenal cortical carcinoma, Carcinosarcoma, Adenosquamous adrenocortical carcinoma, Clear cell adrenal cortical carcinoma.

Adrenocortical carcinoma, also adrenal cortical carcinoma (ACC) and adrenal cortex cancer, is an aggressive cancer originating in the cortex (steroid hormone-producing tissue) of the adrenal gland.