This response is called the acute-phase reaction (also called acute-phase response).

Fever and leukocytosis are features of the acute-phase reaction, while tachycardia is often the initial sign of hemodynamic compromise.

Increase in phospholipase A2 activity is an acute-phase reaction that rises during inflammation, which is also seen to be exponentially higher in low back disc herniations compared to rheumatoid arthritis.

He identified IL-6 as a hepatocyte stimulating factor which induces acute phase reactions.

A normal C-reactive protein can be used to exclude elevated ferritin caused by acute phase reactions.

IL-6 is a multifunctional cytokine which is produced by a large variety of cells and functions as a regulator of immune response, acute phase reactions, and hematopoiesis.

As α1-antitrypsin is an acute phase reaction, its Transcription (genetics) is markedly increased during inflammation elsewhere in response to increased interleukin-1 and 6 and Tumor necrosis factor-alpha production.

In the acute phase reaction, a further elevation is required to "limit" the damage caused by activated neutrophil granulocytes and their enzyme elastase, which breaks down the connective tissue fiber elastin.

Often, it occurs in tandem with an inflammatory disease, as the principal stimulants of platelet production (e.g. thrombopoietin) are elevated in these clinical states as part of the acute phase reaction.

Tumor necrosis factor (TNF, cachexin, or cachectin, and formerly known as tumor necrosis factor alpha or TNFα) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction.

Because one of the functions of elevated ferritin (an acute phase reaction protein) in acute infections is thought to be to sequester iron from bacteria, it is generally thought that iron supplementation (which circumvents this mechanism) should be avoided in patients who have active bacterial infections.