acute monocytic leukemia

Acute monocytic leukemia comprises 3% to 6% of cases and is more common in adults.

They are derived from the peripheral blood of a 1 year old human male with acute monocytic leukemia.

In the summer of 1962, Davis was diagnosed with acute monocytic leukemia and began receiving medical treatment.

Acute monocytic leukemia is far more commonly referenced than the chronic variety.

In acute monocytic leukemia, most of the monocytic cells are promonocytes.

Morphologic and cytochemical features of acute monocytic leukemia include the following:

THP1 is a human monocytic cell line derived from an acute monocytic leukemia patient.

The differential diagnosis includes AML with maturation and acute monocytic leukemia.

M5: acute monocytic leukemia (AMoL).

Acute monoblastic leukemia and acute monocytic leukemia (FAB classifications M5a and M5b).

Acute monocytic leukemia (AMoL, or AML-M5) is considered a type of acute myeloid leukemia.

Acute monoblastic and acute monocytic leukemia are AMLs in which 80% or more of the leukemic cells are of a monocytic lineage.

Almost 30% of cases of acute monoblastic leukemia and 12% of cases of acute monocytic leukemia are associated with 11q23 genetic abnormalities involving the MLL gene.

For example, several miRNAs, including miR-155-5p, are endotoxin-responsive (i.e. lipopolysaccharide, LPS) in the human acute monocytic leukemia cell line, THP1.

Mutation of FLT3, a receptor tyrosine kinase gene, has been observed in about 30% of cases of acute monocytic leukemia (approximately 7% in acute monoblastic leukemia).

An abnormal karyotype has been observed in approximately 75% of cases of acute monoblastic leukemia while approximately 30% of cases of acute monocytic leukemia are associated with an abnormal karyotype.

Cases may correspond morphologically to acute myeloid leukemia with maturation, acute monocytic leukemia, AMML, erythroleukemia, or acute megakaryoblastic leukemia (FAB classifications M2, M5b, M4, M6a, and M7, respectively).