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Pyr1 reversibly stabilizes microtubules, blocks actin microfilament dynamics and inhibits cell motility in vitro.
ACD cross-links monomeric G-actin in the host cell cytosol, preventing formation of actin microfilament, a major component of the cytoskeleton.
Analyzed as a whole, these experiments suggest that the change in cellular phenotype, as a consequence of resveratrol:EC interaction, is dependent on Ca 2+, tyrosine kinases, and intact actin microfilament and microtubules.