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Acid-base imbalances that overcome the buffer system can be compensated in the short term by changing the rate of ventilation.
The model disease was gout, but Berg traced many other "diseases of civilization" to acid-base imbalance, including obesity, arthritis, and diabetes.
Both individual values and ratios among the values are significant; abnormalities among either can indicate problems such as an electrolyte disturbance, acid-base imbalance, or kidney dysfunction.
It absolutely should NOT be used in a patient with cardiorespiratory compromise, hypoxia, or acid-base imbalance with a history of seizure disorders or arrhythmias.
Acid-base imbalance is an abnormality of the human body's normal balance of acids and bases that causes the plasma pH to deviate out of the normal range (7.35 to 7.45).