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I don't think the evidence for there being an X-linked gene was very strong to begin with."
This gene is a member of the brain expressed X-linked gene family.
This disease only requires one copy of the abnormal X-linked gene to display the syndrome.
Here, a complex of proteins bind to the X-linked genes to effectively double their genetic activity.
Second, for individual gene loci, a number of X-linked genes are common through mammalian species.
Genes shown to cause lissencephaly include both autosomal and X-linked genes.
X-linked genes just like autosomal genes have both dominant and recessive types.
The current estimate of sequenced X-linked genes is 499 and the total including vaguely defined traits is 983.
Moreover, no instances were found where an X-linked gene in one species was located on an autosome in the other species.
This is because males inherit their X chromosome and all X-linked genes will be inherited from the maternal side.
But the Canadian researchers, who studied 52 pairs of homosexual brothers, concluded that their results "do not support an X-linked gene underlying male homosexuality."
No person with Aicardi syndrome is known to have transmitted the X-linked gene responsible for the syndrome to the next generation.
These modifications coincide with the transcriptional silencing of the X-linked genes (Morey 2004).
(Males have a single X-chromosome and therefore have only one copy of X-linked genes.)
PGK is the only enzyme in the immediate glycolytic pathway encoded by an X-linked gene.
HDAC8 is an X-linked gene, meaning it is located on the X chromosome.
However, females carring two or more copies of the X chromosome, resulting in a potentially toxic dose of X-linked genes.
Tsix regulates X chromosome dosage compensation in female mice to prevent early embryonic mortality by a dual dose of X-linked genes.
The USP26 gene is an X-linked gene exclusively expressed in the testis and it codes for the ubiquitin-specific protease 26.
Beutler immediately recognized that this might account for the variable expression of X-linked genes in females heterozygous for X-linked mutations.
Tsix allows for equal dosage of X-linked genes for both males and females by inactivating the extra X chromosome in the females.
Even when patients with mutations in X-linked genes (MECP2 and FMR1) are excluded, the gender bias remains.
Typically PDH is the result of a mutation in the X-linked gene for the E1 subunit of the pyruvate dehydrogenase complex.