Von Graefe's sign

Similar to von Graefe's sign, it is observed in people with Graves-Basedow disease, a type of hyperthyroidism.

Von Graefe's sign (lid lag sign) is the immobility or lagging of the upper eyelid on downward rotation of the eye, indicating exophthalmic goiter (Graves' Disease).

In lid-lag (von Graefe's sign), when the patient tracks an object downward with their eyes, the eyelid fails to follow the downward moving iris, and the same type of upper globe exposure which is seen with lid retraction occurs, temporarily.