Sotos syndrome
cerebral gigantism

There is no standard course of treatment for Sotos syndrome.

Provides information and mutual support for families of children with Sotos syndrome.

Sotos syndrome is not a life-threatening disorder and patients may have a normal life expectancy.

People with Sotos syndrome often have intellectual impairment, and most also have behavioral problems.

It remains uncertain whether Sotos syndrome increases the risk of specific types of cancer.

Although most cases of Sotos syndrome occur sporadically, familial cases have also been reported.

About 95 percent of Sotos syndrome cases occur in people with no history of the disorder in their family.

These cases helped researchers determine that Sotos syndrome has an autosomal dominant pattern of inheritance.

The initial abnormalities of Sotos syndrome usually resolve as the growth rate becomes normal after the first few years of life.

A few people with Sotos syndrome have developed cancer, most often in childhood, but no single form of cancer has been associated with this condition.

Sotos syndrome is caused by an abnormality (mutation) in the NSD1 gene.

Sotos syndrome (cerebral gigantism) is a rare genetic disorder characterized by excessive physical growth during the first 2 to 3 years of life.

More examples include Angelman syndrome and Sotos syndrome.

Mutations in the NSD1 gene cause Sotos syndrome.

It is unclear how a reduced amount of this protein during development leads to learning disabilities, overgrowth, and the other features of Sotos syndrome.

Children with Sotos syndrome tend to be large at birth and are often taller, heavier, and have larger heads (macrocephaly) than is normal for their age.

Cerebral Gigantism None Sotos syndrome is a variable genetic disorder characterized by excessive growth before and after birth.

NSD1 is a transcription coregulator protein associated with Sotos syndrome and Weaver syndrome.

It can present in cases of Sensenbrenner syndrome, Sotos syndrome, as well as Marfan syndrome.

Sotos syndrome, a disorder characterized by macrocephaly and caused by a mutation of the NSD1 gene on chromosome 5.

Other signs of Sotos syndrome include an abnormal side-to-side curvature of the spine (scoliosis), seizures, heart or kidney defects, hearing loss, and problems with vision.

Developmental delays are present in most children with Sotos syndrome and can include motor and language delays as well as mental retardation ranging from mild to severe.

In the Japanese population, the most common genetic change leading to Sotos syndrome deletes genetic material from the region of chromosome 5 containing the NSD1 gene.

Bone age may be significantly advanced in genetic overgrowth syndromes, such as Sotos syndrome, Beckwith-Wiedemann syndrome and Marshall-Smith syndrome.

Diagnosis of Perlman syndrome also overlap with other disorders associated with Wilms tumor namely Sotos syndrome and Weaver syndrome.

Sotos syndrome (cerebral gigantism) is a rare genetic disorder characterized by excessive physical growth during the first 2 to 3 years of life.

Mr. Gunther, 43, has cerebral gigantism, and the excess of growth hormone produced by his pituitary gland has made him extremely large.

Cerebral Gigantism None Sotos syndrome is a variable genetic disorder characterized by excessive growth before and after birth.