RHO kinase

This results in upregulation of RhoA/RhoC, Rho kinase activation and tumour cell invasion.

MLCP activity is inhibited by Rhoa and Rho kinase, components of the Ca independent pathway for maintaining muscle contraction.

NgR is a membrane protein that, when bound to neurite outgrowth inhibitor (Nogo), inhibits cell growth through the activation of rho kinase (ROCK).

Downstream of LPA receptor activation, the small GTPase Rho can be activated, subsequently activating Rho kinase.

This protein is also involved in regulating the cellular localization of the KRIT1 protein and acts with the Rho Kinase signaling pathway to maintain normal blood vessel structure.

A number of kinases such as Rho kinase, Zip kinase, and Protein Kinase C are believed to participate in the sustained phase of contraction, and calcium flux may be significant.

Other cell signaling pathways and protein kinases (Protein kinase C, Rho kinase, Zip kinase, Focal adhesion kinases) have been implicated as well and actin polymerization dynamics plays a role in force maintenance.

They show that the combination of irradiated fibroblast feeder cells(a review is given in and) and Rho kinase inhibitor, Y-27632, conditionally induces an indefinite proliferative state with unknown mechanisms (at least partially due to telomerase induction) in primary mammalian epithelial cells.

In DRG neurons, CRMP-2 is phosphorylated by Rho kinase in LPA signaling but not in Sema3A signaling, revealing the presence of both Rho kinase-dependent and Rho kinase-independent pathways for the growth cone collapse.