PML nuclear body

The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles.

BLM is localized in nuclear bodies and the nucleolus The BLM DNA helicase is found in two distinct nuclear structures in normal human cells, ND10 or PML nuclear bodies (NBs) and the nucleolus [ 20].

After translocating to the nucleus early in infection, ICP0 promotes degradation of many cellular antiviral genes, including those for nuclear body-associated proteins promyelocytic leukemia protein (PML) and Sp100, causing disruption of PML nuclear bodies and reduced cellular antiviral capacity.