proliferating cell nuclear antigen , PCNA (Abkürzung)

Pleiomorphic pattern is caused by antibodies to the proliferating cell nuclear antigen.

Proliferating cell nuclear antigen immunohistochemical technique although a promising method of assessing cell proliferation has yet to be fully standardised.

Eukaryotes have a clamp loader complex and a six-unit clamp called the proliferating cell nuclear antigen.

This process involves proliferating cell nuclear antigen, the single strand-binding protein replication protein A and NS1.

A bypass platform is provided to these polymerases by Proliferating cell nuclear antigen (PCNA).

Two proliferation markers, proliferating cell nuclear antigen (PCNA) and Ki-67, have been extensively studied in this context.

In eukaryotes, the sliding clamp is a homotrimer ring structure known as the proliferating cell nuclear antigen (PCNA).

An example of such a DNA clamp is PCNA (proliferating cell nuclear antigen) found in S. cervesiae.

PCNA - Proliferating Cell Nuclear Antigen, expressed during the DNA synthesis.

Antibodies against proliferating cell nuclear antigen (PCNA) or monoclonal antibody termed Ki-67 can be used for grading of different neoplasms, e.g. astrocytoma.

The polymerase is held on the DNA strand by PCNA (Proliferating Cell Nuclear Antigen).

The sliding clamp in eukaryotes is assembled from a specific subunit of DNA polymerase delta called the proliferating cell nuclear antigen (PCNA).

Primary antibodies were obtained from commercial sources for detection of proliferating cell nuclear antigen (PCNA, Oncogene Science, Cambridge, MA) and actin (Sigma).

Studies of crypts labelled in vivo with BrdUrd may provide a reference against which other putative intrinsic proliferation markers such as Ki-67 and proliferating cell nuclear antigen may be assessed.

Densitometric analysis of data from 3 experiments similar to that shown in Figure 2Brevealed no significant effect of 4-AP treatment on the expression of proliferating cell nuclear antigen (PCNA).

Replication factor C (RFC) loads the Proliferating Cell Nuclear Antigen (PCNA) onto the DNA strand.

Proliferating Cell Nuclear Antigen, commonly known as PCNA, is a protein that acts as a processivity factor for DNA polymerase δ in eukaryotic cells.

These include the enzymes DNA polymerase family B, the topoisomerase II A, the Flap endonuclease and the processing factor Proliferating Cell Nuclear Antigen.

Further research implicates the supplementary role of Proliferating cell nuclear antigen (PCNA) to DNA Ligase I's function of joining Okazaki fragments.

The TCP domain is necessary for specific binding to promoter elements of the Proliferating cell nuclear antigen (PCNA) gene and also in DNA binding.

DNMT1 is the most abundant methyltransferase in somatic cells, localizes to replication foci, has a 10-40-fold preference for hemimethylated DNA and interacts with the proliferating cell nuclear antigen (PCNA).

This is because the FFAA mutation keeps FEN1 from interacting with PCNA (proliferating cell nuclear antigen), consequently not allowing it to complete its purpose during Okazaki fragment maturation.

The specialised histological type is associated with a higher rate of cell turnover as shown by thymidine labelling and a higher proportion of cells in cycle (by proliferating cell nuclear antigen immunolocalisation) than junctional and fundic types.

Proliferation markers based on the immunocytochemical finding of endogenous antigens such as Ki67 or proliferating cell nuclear antigen (PCNA) generally express a wider range of the cell cycle, but their application in clinical practice is considerably less complex.

These methods are based on a monoclonal antibody against 5-bromo-2-deoxyuridine (BrdU), which is confined to S phase cells, and a more broad assessment of proliferation based on an antibody against proliferating cell nuclear antigen (PCNA, clone 19A2).