peak acid output , PAO (Abkürzung)

The H pylori negative and positive healthy volunteers were similar for both basal and peak acid output.

Increased basal and peak acid output was also prevalent in the patients with idiopathic DU.

Subjects with atrophy had lower mean sham fed, maximal, and peak acid output than all other subjects (Fig 3).

Peak acid output was calculated by adding the two highest stimulated 15 minute outpts and multiplying by two.

Peak acid output was defined as the two highest consecutive 15 minute outputs after pentagastrin, multiplied by two to express the results as mmol/h.

Our present findings are consistent with the generally accepted view that peak acid output reflects the parietal cell mass and is not altered by eradication of H pylori.

After this, pentagastrin (6 g/kg) was administered subcutaneously and gastric juice was collected for a further 60 minutes for estimation of maximal and peak acid output.

Using multiple linear regression, only the presence of gastritis with atrophy was independently and negatively associated with sham fed, maximal, and peak acid output (Table II).

In the rest of the patients with idiopathic DU three disturbances of gastric function are prevalent: hypergastrinaemia, increased basal and peak acid output, and rapid gastric emptying.

The increased peak acid output to pentagastrin in the patients with idiopathic DU and H pylori positive patients with DU indicates that both have an increased parietal cell mass.

Piubello et al found acid hypersecretion in a group of 21 chronic alcoholic patients and the peak acid output values in these patients were similar to those measured in patients with duodenal ulcers and was significantly higher than those in control groups.

These include high basal and peak acid outputs, a high ratio of basal to peak acid secretion, increased meal stimulated acid output, and impairment of the normal inhibition of gastrin release and acid secretion by luminal acid.

Results were expressed as basal acid output (BAO), defined as the mean of the last two recordings during the basal collection, and peak acid output (PAO) defined as the highest mean obtainable from two consecutive recordings during the stimulated period.