P-toluenesulfonic acid

Pyridinium p-toluenesulfonate is a salt of pyridine and p-toluenesulfonic acid.

Sulfonation occurs on the side chains, not on the aromatic rings, like in p-toluenesulfonic acid.

In this example, isophorone was protected using ethylene glycol with p-toluenesulfonic acid in moderate yield.

Deprotection: P-toluenesulfonic acid, acetone, and water.

The condensation of 1,4-dialkoxy-2,5bis(alkoxymethyl)benzene catalyzed by p-toluenesulfonic acid.

European and Japanese companies use the reaction of sodium tert-butylate with carbon dioxide, catalysed by p-toluenesulfonic acid or methanesulfonic acid.

Tosylate, the anion of p-toluenesulfonic acid (written as OTs or TsO)

Collidinium p-toluenesulfonate or CTPS is a salt between p-toluenesulfonic acid and collidine (2,4,6-trimethylpyridine).

The MOM-ether can be removed using methanol in the presence of p-toluenesulfonic acid as an alternative to aqueous acid.

Bronsted acids such as HCl, HSO, polyphosphoric acid and p-toluenesulfonic acid have been used successfully.

A green chemistry procedure was recently developed using solvent-free conditions: resorcinol, an aldehyde, and p-toluenesulfonic acid are ground together in a mortar and pestle at low temperature.

Pyridinium p-toluenesulfonate (PPTS) is an illustrative pyridinium salt; it is produced by treating pyridine with p-toluenesulfonic acid.

Cetyl myristoleate has been prepared by an esterification reaction between myristoleic acid and cetyl alcohol in benzene, catalyzed by p-toluenesulfonic acid monohydrate.

Methanesulfonic acid is convenient for industrial applications because it is liquid at ambient temperature, while the closely related p-toluenesulfonic acid (PTSA) is solid.

In the reaction between cyclohexanone and nitrostyrene sketched below, the base proline is derivatized and works in conjunction with a protic acid such as p-toluenesulfonic acid:

It undergoes smooth sulfonation to give p-toluenesulfonic acid, and chlorination by Cl in the presence of FeCl to give ortho and para isomers of chlorotoluene.

This was done by adding an excess amount of a 1,2- or 1,3- diol to the NanoKid in the presence of a catalytic amount of p-toluenesulfonic acid and microwave oven-irradiation.

Removal of the silyl protecting group with p-toluenesulfonic acid to alcohol 4b and ring-closure by azeotropic distillation returns the compound to lactone 5 (direct alkylation of 1 met with undisclosed problems).

The 3,4-pentylidene acetal mesylate is prepared in three steps: esterification with ethanol and thionyl chloride; ketalization with p-toluenesulfonic acid and 3-pentanone; and mesylation with triethylamine and methanesulfonyl chloride.

In 2005, research produced a pyrogallol[4]arene by simply mixing a solvent-free dispersion of isovaleraldehyde with pyrogallol and a catalytic amount of p-toluenesulfonic acid in a mortar and pestle.

The reaction is catalyzed by Lewis acids such as tin tetrachloride and scandium(III) triflate and Brønsted acids such as p-toluenesulfonic acid, perchloric acid, amberlite and iodine.

Treating a ketone or aldehyde with ethylene glycol in the presence of an acid catalyst (e.g., p-toluenesulfonic acid; BF-EtO) gives the corresponding a 1,3-dioxolane, which is resistant to bases and other nucleophiles.

In solution-phase synthesis, acidic conditions are essential; formic acid, acetic acid, and propionic acid are typical reaction solvents, or p-toluenesulfonic acid or various Lewis acids can be used with a non-acidic solvent.

Tosylate refers to the anion of p-toluenesulfonic acid (CHCHSO) and it is abbreviated as TsO, or it may refer to esters of p-toluenesulfonic acid.

In one study oxazoles were prepared via a one-pot synthesis consisting of the condensation of propargyl amine and benzoyl chloride to the amide, followed by a Sonogashira coupling of the terminal alkyne end with another equivalent of benzoylchloride, and concluding with p-toluenesulfonic acid catalyzed cycloisomerization: