olivopontocerebellar atrophy , OPCA (Abkürzung)

Olivopontocerebellar atrophy is hereditary, but has an unknown genetic basis.

It is sometimes termed sporadic olivopontocerebellar atrophy.

Dejerine-Thomas olivopontocerebellar atrophy: A sporadically occurring form of chronic progressive ataxia.

Lastly, it has been found that people suffering from malaria and patients with olivopontocerebellar atrophy have raised quinolinic acid metabolism.

One disorder (called olivopontocerebellar atrophy, or OPCA) causes problems with balance, coordination, and speech.

Additionally, there is a hereditary form of olivopontocerebellar atrophy that is not part of the multiple system atrophy spectrum.

Damage to the cerebellum can occur through a number of causes including trauma, alcoholism, chronic degenerative diseases such as olivopontocerebellar atrophy, and genetic developmental disorders.

The term now encompasses three conditions once thought to be separate disorders, specifically Shy-Drager syndrome, striatonigral degeneration, and sporadic olivopontocerebellar atrophy.

Additional Parkinson-plus syndromes include Pick's disease and olivopontocerebellar atrophy (OPCA).

Olivopontocerebellar atrophy (OPCA) is the degeneration of neurons in specific areas of the brain - the cerebellum, pons, and inferior olives.

Ataxin 7 is a protein associated with both olivopontocerebellar atrophy type 3 (OPCA3) and spinocerebellar ataxia type 7 (SCA7).

Disorder subdivisions: Friedreich's ataxia, Spinocerebellar ataxia, Ataxia telangiectasia, Vasomotor ataxia, Vestibulocerebellar, Ataxiadynamia, Ataxiophemia, Olivopontocerebellar atrophy, and Charcot-Marie-Tooth disease.

Synonyms for autosomal dominant cerebellar ataxias (ADCA) used prior to the current understanding of the molecular genetics were Marie's ataxia, inherited olivopontocerebellar atrophy, cerebello-olivary atrophy, or the more generic term "spinocerebellar degeneration."

A few non-hereditary diseases formerly categorized as olivopontocerebellar atrophy have been reclassified as forms of multiple system atrophy as well as to four hereditary types, that have been currently reclassified as four different forms of spinocerebellar ataxia: