Nissl granules
Nissl substance

These cells characteristically present coarse Nissl granules and have characteristic eccentric nuclei.

Can be used for staining Golgi apparatus in cells and Nissl granules in neurons.

Individual granules of extranuclear RNA are named Nissl granules (ribosomes).

A high amount of protein synthesis occurs in this region, as it contains a large number of Nissl granules (which are ribosomes wrapped in RER) and polyribosomes.

The soma (main part of the neuron in which the dendrites branch off of) contains many organelles, including granules called Nissl granules, which are composed largely of rough endoplasmic reticulum and free polyribosomes.

It is used to demonstrate the nissl substance in the neurons and cell nuclei.

Neutral red (or toluylene red) stains Nissl substance red.

Chromatolysis is still used as a term to distinguish the particular apoptotic process in the neuronal cells, where Nissl substance disintegrates.

Ganglion cells can appear immature and atypical, they can be bi- or multinucleated and showing evidence of Nissl substance (2-6).

The Nissl substance (rough endoplasmic reticulum) appears dark blue due to the staining of ribosomal RNA, giving the cytoplasm a mottled appearance.

The prominence of the Nissl substance can be explained by the fact that nerve cells are metabolically very active, and hence are involved in large amounts of protein synthesis.

Nerve cell bodies stained with basophilic dyes show numerous microscopic clumps of Nissl substance (named after German psychiatrist and neuropathologist Franz Nissl, 1860-1919), which consists of rough endoplasmic reticulum and associated ribosomal RNA.