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But nevirapine should still be used for two other groups, the centers said.
Nevirapine was the most common cause of the unwanted effects.
Nevirapine is already widely used to protect babies at birth.
"We know that in many settings the single dose of nevirapine is the only option," he said.
These modest doses mean that developing countries should be able to afford nevirapine.
The principal authors suggested that infants might therefore need more nevirapine.
An analysis of the early nevirapine trials showed similar results above and below 100,000 viral load.
One regimen was single dose nevirapine therapy for mother and infant.
Under those circumstances, nevirapine is usually harmless and cuts in half the chance that the baby will get infected.
No deaths occurred among the mothers who took nevirapine.
Nevirapine has been more associated with skin rash and liver toxicity.
After the initial 12-week period, frequent clinical and laboratory monitoring should continue throughout nevirapine treatment.
Only after a 2002 court order did the government begin providing nevirapine to prevent women from infecting their babies.
Nevirapine is a common choice because of its cost and can be used in women of child-bearing age.
Officials say they also want to watch for possible side-effects of nevirapine before distributing it more widely.
Some who developed "nevirapine rash," or nerve tingling, cut back.
The study found that the single dose of nevirapine protected a breast-fed baby from infection for six weeks.
Boehringer-Ingelheim, which makes nevirapine, the cheaper and easier to use of the two effective drugs, gives it away in many poor countries.
A higher dose of 300/75mg/m2 should be considered when co-administered with efavirenz or nevirapine.
It is thought the TB drugs speed up the breakdown of nevirapine in the body.
Nevirapine is still prescribed legally in the United States.
The government's existing nevirapine program reaches about 90,000 women a year, about 10 percent of those who give birth annually.
Ziduvodine and nevirapine were already on it for mother-child transmission, but can now be given to adults.
Nevirapine may cause severe or life-threatening liver toxicity, usually emerging in the first six weeks of treatment.
Nevirapine: a review of its development, pharmacological profile and potential for clinical use Exp.